The overall aim of the project is to define and track the pathogenic B-cell clones and autoantibodies driving multifocal motor neuropathy (MMN), and to use this knowledge to inform targeted, disease-modifying therapeutic strategies. The project integrates advanced immunophenotyping, single-cell approaches, B-cell receptor sequencing, antibody cloning, in vitro functional assays (including human iPSC-derived motor neuron systems), and longitudinal immune monitoring.
The post-holder will work under the joint supervision of Prof Simon Rinaldi (Oxford) and Dr Nicolas Dubuisson (Oxford/UCLouvain). The first 18 months will be based in Oxford, focusing on detection and characterisation of pathogenic B-cell clones and antibody cloning. The remaining 18 months will be spent at UCLouvain (Belgium), developing downstream antibody production, characterisation, and therapeutic testing pipelines, while remaining employed by the University of Oxford.
The post offers an outstanding opportunity to contribute to a high-impact translational programme, develop independent scientific expertise in autoimmune neurology and B-cell immunology, and gain experience across two leading European centres.
Please see the ‘Job Description’ for further details on the role, responsibilities, and selection criteria, as well as further information about the university and how to apply.
This post is full time and fixed term for 3 years in the first instance.
Only applications received before midday 12:00 on Monday 8th June 2026 will be considered.
Interviews will be held as soon as possible thereafter.
Official Application Link
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